Protein transduction therapy into cochleae via the round window niche in guinea pigs
نویسندگان
چکیده
منابع مشابه
Protein transduction therapy into cochleae via the round window niche in guinea pigs
Cell-penetrating peptides (CPPs) are short sequences of amino acids that facilitate the penetration of conjugated cargoes across mammalian cell membranes, and as such, they may provide a safe and effective method for drug delivery to the inner ear. Simple polyarginine peptides have been shown to induce significantly higher cell penetration rates among CPPs. Herein, we show that a peptide consis...
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This study evaluated the histopathologic changes in the round window niche. , and membrane in cases of chronic suppurative otitis media. The pathologic process was found in all subjects. Fibrocystic or fibrous tissue was most commonly seen, while active granulation was less developed. The round window membrane was thicker and inflamed throughout its layers. Inflammatory invasion of the inne...
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In order to analyze the entry of solutes through the round window membrane, a quantitative description of round window anatomy in relationship to scala tympani is required. High-resolution magnetic resonance microscopy was used to visualize the fluid spaces and tissues of the inner ear in three dimensions in isolated, fixed specimens from guinea pigs. Each specimen was represented as consecutiv...
متن کاملthe. round window niche and membrane in chronic suppurative otitis media
this study evaluated the histopathologic changes in the round window niche. , and membrane in cases of chronic suppurative otitis media. the pathologic process was found in all subjects. fibrocystic or fibrous tissue was most commonly seen, while active granulation was less developed. the round window membrane was thicker and inflamed throughout its layers. inflammatory invasion of the inner ea...
متن کاملRibbon Synapse Plasticity in the Cochleae of Guinea Pigs after Noise-Induced Silent Damage
Noise exposure at low levels or low doses can damage hair cell afferent ribbon synapses without causing permanent threshold shifts. In contrast to reports in the mouse cochleae, initial damage to ribbon synapses in the cochleae of guinea pigs is largely repairable. In the present study, we further investigated the repair process in ribbon synapses in guinea pigs after similar noise exposure. In...
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ژورنال
عنوان ژورنال: Molecular Therapy - Methods & Clinical Development
سال: 2016
ISSN: 2329-0501
DOI: 10.1038/mtm.2016.55